Eye health support

 

Effects of a combination of polyphenol-rich extracts on the protection of retinal cells against blue light in the prevention of ocular diseases. (Commercial product Retico®)

  1. Bioethics Committee Approval Number:
    (12)17/2023/24.01.2023
  2. NCT Number:
    clinicaltrials.gov
  3. Status:
    study completed

The aim of the study is to determine the protective effect of a standardized mixture of extracts and the comprehensive product (RETICO®) on potential retinal cell damage caused by exposure to blue light.

Blue light, penetrating through the lens to the retina, causes photochemical or thermal damage. Prolonged exposure to blue light can irreversibly damage the photosensitive cells of the retina, leading to inflammation and diseases such as dry eye syndrome or changes resembling age-related macular degeneration (AMD), which can even result in permanent vision loss [1].

Berry extracts, rich in polyphenols and anthocyanins, reduce the production of reactive oxygen species and inhibit changes in mitochondrial membrane potential, which are associated with retinal cell death via apoptosis [2]. Rutin has antioxidant effects, strengthens blood vessel walls, and stimulates blood circulation [3]. B vitamins (B6, B9, and B12) reduce homocysteine levels—a protein that contributes to the development of macular degeneration [4].

The study includes the following groups:

  • receiving a placebo,
  • receiving a standardized mixture of extracts,
  • receiving the comprehensive product – RETICO®.

The study group consists of adults exposed to blue light radiation for at least 6-8 hours per day.

As part of the study, ophthalmological examinations will be conducted to assess the condition of the visual organ and to identify any potential visual field defects caused by blue light exposure. Subjective symptoms related to the visual organ, as experienced by the patient, will be evaluated using the Visual Analog Scale and the DEQS questionnaire.

[1] Zhao ZC, Zhou Y, Tan G, Li J. Research progress about the effect and prevention of blue light on eyes. Int J Ophthalmol. 2018 Dec 18;11(12):1999-2003.

[2] Majumdar S, Srirangam R. Potential of the bioflavonoids in the prevention/treatment of ocular disorders. J Pharm Pharmacol. 2010 Aug;62(8):951-65.

[3] Ganeshpurkar A, Saluja AK. The Pharmacological Potential of Rutin. Saudi Pharm J. 2017 Feb;25(2):149-164.

[4] Gorusupudi A, Nelson K, Bernstein PS. The Age-Related Eye Disease 2 Study: Micronutrients in the Treatment of Macular Degeneration. Adv Nutr. 2017 Jan 17;8(1):40-53.